Endocrine Abstracts

Objective: It has been argued that salivary alpha-amylase (sAA) is a potential indirect sympathoadrenal medullary (SAM) system activity marker. This study aimed to look at sAA to assess the sympathetic nervous system in acromegaly patients.Subjects and Methods: A total of 31 individuals with acromegaly and 30 controls were enrolled in this prospective, single-center investigation. Saliva samples were taken from individuals with acromegaly and controls in...

Introduction: Primary hyperparathyroidism (PHPT) occurs a peak incidence between ages 50 and 60 and the classical bone disease of PHPT or pathological fractures due to PHPT is rarely seen today. Furthermore brown tumor detected with Tc-99m MIBI scintigraphy exists in literature infrequently.Case: A 23 years old woman presented with left arm pain admitted in Department of Orthopaedics for pathological fracture in left humerus. As a result of investigation...

Introduction: Thyrotropin secreting pituitary adenomas are rare constituting <2% of pituitary adenomas. Thirty percent of these tumors may be plurihormonal. Most common cosecreted hormone is GH and the least one is PRL. We report here a case of plurihormonal pituitary adenoma symptomatic for TSH secretion.Case report: A 35-year-old female admitted to hospital because of fatigue, heat intolerance, headache, galactorrhea and menstrual irregularity. Her...

Introduction: Sertoli–Leydig cell tumours are rare tumours which account for <1% of all solid ovarian tumors. It mostly occurs in 2–4° decades of life. Rapidly progessing symptoms/signs of androgen excess suggest the presence of and androgen secreting tumor.Case: Two postmenopausal patients (50 and 57 year-old) were referred to our Endocrinology Clinic for evaluation of worsening hirsutism. Both of patients had manifestations of hypera...

ObjectiveScanty data about glucose metabolism, hypertension and metabolic syndrome (MS) have been reported in Paget’s disease of bone (PDB) to be related with increased cardiovascular mortality. We aimed to determine prevalence of metabolic syndrome in PDB and to determine the relationship between metabolic syndrome and bone-specific alkaline phosphatase levels.Patients and methodsTwenty three patients w...

Introduction: Recently, Programmed cell death ligand 1 (PD-L1) inhibitors have been frequently used as promising treatment options for some advanced malignancies. Although immune-related side effects secondary to PD-1 inhibitor treatment are well defined in the literature, data on PD-L1 inhibitors are limited. Thyroid dysfunction was reported in 10% of patients in the clinical study of atezolizumab. We aimed to present a case of severe hypothyroidism-related rhabdomyolysis and...

Purpose: To determine the relationship between grade of diabetic retinopathy and serum vitamin D levels in diabetic patients.Materials and methods: A total of 173 diabetic patients consisting of patients without retinopathy (n=67), patients with non proliferative diabetic retinopathy (NPDRP group n=47), patients with proliferative diabetic retinopathy (PDRP group n=59) was included in the study. Age and sex matched 55 healthy s...

ObjectiveIn patients with Cushing’s disease (CD), normal pituitary corticotrophs are suppressed by excessive and persistent cortisol secretion in responce to autonomous ACTH secretion by tumour. Therefore, patients exhibit signs and symptoms of ACTH deficiency shortly after resection of tumour and need steroid replacement therapy (SRT) until hypotalamo-pituitary-adrenal (HPA) axis recovery. We aimed to evaluate whether duration of SRT can serve as a...

PurposeWe aimed to determine the effectiveness of bilateral inferior petrosal sinus sampling (IPSS) in the differential diagnosis of adrenocorticotropic hormone-dependent Cushing Syndrome (ACTH-dependent CS).Method51 patients diagnosed with ACTH-dependent CS between 2010-2019 in the Endocrinology Clinic in Şişli Hamidiye Etfal Health Training and Research Hospital were included in the study. The dia...

Introduction: Atypical parathyroid tumour (APT) is a rare cause of primary hyperparathyroidism (PHPT) with a frequency of 1.2-1.3%. APT is a lesion with suspicious clinical and histological features of malignancy which does not completely respect the World Health Organization (WHO) criteria for diagnosis of Parathyroid Carcinoma (PC). There is a well-known association with PHT and medullary thyroid carcinoma for multiple endocrine neoplasia. However, concurrence of thyroid pap...